Regional distribution of solute carrier (SLC) mRNA expression along the human intestinal tract
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چکیده
240 words Introduction: 559 words Discussion: 953 words Abbreviations: SLC, solute carrier; CNT, concentrative nucleoside transporter; ASBT, apical sodium-dependent bile acid transporter; SERT, serotonin transporter; PEPT, peptide transporter; OCTN, organic zwitterion/cation transporter; OATP, organic anion transporting polypeptide; ENT, equilibrative nucleoside transporter; IBD, inflammatory bowel disease; 5HT, 5-hydroxytryptamine; IBS, irritable bowel syndrome; OCT, organic cation transporter; MCT1, monocarboxylate transporter; OAT, organic anion transporter; ca, colon ascendens; ct, colon transversum; cd, colon descendens. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on January 12, 2007 as DOI: 10.1124/dmd.106.013342 at A PE T Jornals on Jne 6, 2017 dm d.aspurnals.org D ow nladed from
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Regional distribution of solute carrier mRNA expression along the human intestinal tract.
Intestinal absorption of drugs, nutrients, and other compounds is mediated by uptake transporters expressed at the apical enterocyte membrane. These compounds are returned to the intestinal lumen or released into portal circulation by intestinal efflux transporters expressed at apical or basolateral membranes, respectively. One important transporter superfamily, multiple members of which are in...
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